Endocrine Abstracts

It has been shown that miR-107 regulates insulin sensitivity, but its status in severe insulin resistance (IR) patients has not been established. In this study, we investigated the expression of microRNA-107 in the sera from patients with clinically severe IR and its relationships with metabolic characteristics.Methods: The expression of microRNA-107 was detected in the sera of 30 clinically severe IR patients and 24 gender and age-matched control group ...

Introduction: Adipose tissue is a major source of adipocytokines. It plays an important role for the development of insulin resistance (IR). Data implicate that incretins enhance insulin sensitivity. One aspect of the pathophysiology of gestational diabetes (GDM) is IR. The relationship between adipocytokines, incretins and GDM might be closely associated.Aim: To evaluate the coherence of adipocytokines (adiponectin and leptin), incretins (GLP-1, GIP), i...

Introduction: There is growing evidence that gestational diabetes mellitus (GDM) significantly increases the risk of adverse consequences, the most significant of which is a predisposition to the development of metabolic syndrome and diabetes mellitus (DM). The reasons why some women develop DM, while the others not, are still studied. The relationship between various metabolic parameters and GDM might be closely associated.Aim: To evaluate the coherence...

Objective: The aim of the study was to determine frequency of insulin resistance, in individuals with type 1 diabetes mellitus and the link between insulin resistance and cardiovascular disease, sex hormones. The task of the research is to determine the frequency of insulin resistance among people with diabetes mellitus type 1. To determine association between eGDR and age, sex, cardiovascular disease, chronic complications of diabetes and sex hormones. To determine associatio...

Introduction: TCF7L2 is a commonly investigated gene in women with gestational diabetes mellitus (GDM). TCF7L2 different SNP‘s are associated with GDM risk in women of different races and ethnicities, however, the relationship between the genetic variants of TCF7L2 and GDM has not been completely evaluated.Objective: To determine the association of genetic variants rs7901695, rs7903146, rs7895340, rs11196205, rs12255372 of...